The Hidden Repertoire: Neoself-Antigens in Lupus and Cancer

Immune cells in Lupus target neoself-antigens!

Neoself antigens are parts of a normal protein that are naturally NOT presented on HLA complexes, but due to dysregulation in disease, such as after EBV infection, get presented.
HLA-peptide presentation is also dysregulated in cancer.

We see this daily in our HLA-peptide database HLA-Compass. We have identified thousands of peptides that are specifically presented in cancer tissues, but not on healthy cells, representing potential targets for precisionmedicine.

immunopeptidomics Tcells cellandgenetherapy