Publications

Proteogenomic Discovery of Novel Open Reading Frames With HLA Immune Presentation on Human β-Cells

Alithea Bio is proud to share its latest peer-reviewed publication, a breakthrough study led by Dr. Daniel Hwang in collaboration with the labs of John Maris, Mustafa Mir, and Andrea Facciabene.

This research introduces HLA-Shuttle (tapasin-TM), a transformative technology designed to overcome immune evasion in “cold” tumors like neuroblastoma. By restoring HLA class I antigen presentation, this approach unmasks hundreds of previously invisible therapeutic targets, paving the way for more effective CAR-T, TCR-T, and Cancer Vaccines.

Key Breakthroughs:

• Restores Detection: Overcomes HLA-I downregulation to “heat up” cold tumors.

• Antigen Discovery: Identifies hundreds of new targets for immunotherapy.

• Enhanced Killing: Stabilizes HLA-I trafficking to boost T cell-mediated tumor destruction.

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Proteogenomic Discovery of Novel Open Reading Frames With HLA Immune Presentation on Human β-Cells

Alithea Bio is proud to share its first peer-reviewed publication affiliated with our research team, published in Diabetes Journal.
This study introduces a proteogenomic approach to identify novel open reading frames (nuORFs) in human β-cells, advancing understanding of translational regulation and immune presentation in diabetes.

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