Off-Target Toxicity in Immunotherapy: Identification and Mitigation Strategies

To prevent off-target effects, researchers need more than just a list of peptides; they need
quantification. Knowing a peptide is present on a lung cell isn’t enough—you need to know how
much is there compared to the tumor.
Alithea Bio’s off-target toxicity prediction workflow uses the HLA-Compass database to
compare target candidates against an atlas of healthy tissues. By providing relative
quantification between thousands of samples, we help clinical-stage companies decide which
TCR candidates are safe for human trials and which should be discarded.