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info2 Fine-tuning immunotherapy treatment by deciphering HLA-peptide T cell interactions Fine-tuning immunotherapy treatment by deciphering HLA-peptide T cell interactions THE PRECISION IMMUNOTHERAPY COMPANY keyboard_arrow_left

info2 Alithea’s M/ZOOM™ technology applies HLA peptide purification in combination with highly sensitive and reproducible mass spectrometry. With M/ZOOM™, it is possible to specifically target epitopes from certain genetic regions of interest. info2b NEOZOOM™
detecting neo-epitopes on tumour cells with unprecedented sensitivity
Based on M/ZOOM™, Alithea has developed specific products for different applications: CONZOOM™
detecting epitopes from specific genetic constructs
detecting epitopes from therapeutic proteins for immunogenicity assessment
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1 Alithea’s highly sensitive and reproducible HLA peptidome characterization can support the development of a variety of therapeutic options especially in the immunotherapy space. 2 Target discovery and validation
HLA-presented peptides represent the natural target of TCR T-cell therapies and TCR-mimic antibodies. Also when developing vaccines, knowledge of which antigen-derived peptides are presented on HLA complexes can be required.
TCR T-cell therapy TCR-mimic antibody Vaccines
3 Quality control and safety
Several approaches for the induction of tumor-specific T cells have been developed. If the desired peptides, but not undesired peptides are presented on a patient's HLA alleles are important quality and safety determinants. Alithea's CONZOOM technology is especially suited to answer these questions.
4 Immunogenicity assessment
Therapeutic proteins such as antibodies, can be immunogenic in patients. This applies not only to protein therapeutics but also to CAR T constructs and any other gene therapy product that is translated to a protein.
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Neozoom Neozoom: revolutionizing neoantigen discovery
Neoepitope-targeted therapies such as cancer vaccines and TCR-engineered T cell therapy are currently some of the most promising novel therapies.

Exact knowledge of which neoepitopes are presented by tumor cells are essential. Classical mass spectrometric strategies are limited by sensitivity or throughput and can rarely detect any neoepitopes.

Alithea’s NEOZOOM™ strategy was developed to increase sensitivity and detectability of neoepitopes and clearly outperforms classical strategies.
Conzoom Conzoom: revolutionizing targeted epitope discovery
During target discovery and quality control of certain immunotherapies, it is of interest to idetify and quantify presentation of epitopes from specific genetic elements of interest.

Our CONZOOM™ technology allows to scan for gene- or construct-derived epitopes in high sensitivity and allows to optimally design follow-up experiments to profile T cell subsets by tetramers or ELISPOT assays.
Immzoom Immzoom: revolutionizing immunogenicity assessment
A risk in the development of therapeutic proteins is the generation of high affinity anti-drug antibodies (ADA). After treatment with therapeutic proteins (Antibody, other protein drug and even CAR T-cells), it is possible that the patients' immune system responds to the drug and neutralizes it reducing efficacy of the treatment.

By assessing HLA-presented peptides, it is possible to study these immune processes. IMMZOOM allows for highly sensitive and reproducible detection of drug-derived antigens presented on HLA class II complexes.
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About Alithea Bio has laboratories located in a Biotech hotspot in central Europe close to Basel, Munich, Heidelberg at the École Supérieure Biotechnologique de Strasbourg

Alithea Bio UG (haftungsbeschränkt)
Liebühl 2A
79104 Freiburg im Breisgau

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